ICD 10 Coding for Status Post Cholecystectomy Melanosis coli Quantitative Analysis of Melanosis Coli Colonic Mucosa Using Textural Patterns Melanosis coli: Symptoms, causes, treatment, and more Melanosis coli is dark brown black pigmentation of colorectal mucosa associated with chronic use of laxatives containing anthraquinone. Examples of such laxatives include senna and rhubarb derivatives. Clinical Importance: There is no association MELANOSIS COLI** Melanosis coli is a disorder of pigmentation of the bowel wall. Histology demonstrates pigment laden macrophages It is associated with laxative abuse, especially **anthraquinone compounds such as senna**