Oxidative Stress in Non Dialysis Dependent Chronic Kidney Disease Patients The appeal of glutathione injections makes sense. Glutathione is one of the most important antioxidants your body produces, and levels drop as you age, making the idea of a quick boost tempting. Glutathione deficiency alters the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD fed mice ScienceDirect Increase in renal glutathione in cholestatic liver disease is due to a direct effect of bile acids American Journal of Physiology Renal Physiology American Physiological Society Disruption in glutathione metabolism and altered energy production in the liver and kidney after ischemic acute kidney injury in mice Scientific Reports What Is Glutathione? Purifi IV