The main mechanisms of MTX toxicity in experimental disease models of Download Scientific Diagram Full article: L methionine protects against nephrotoxicity induced by methotrexate through modulation of redox status and inflammation Epicatechin ameliorative effects on methotrexate induced hepatotoxicity in mice Reza Azadnasab, Hadi Kalantar, Layasadat Khorsandi, Heibatullah Kalantari, Mohammad Javad Khodayar, 2021 Leucovorin (Folinic Acid) The Rescue Drug! Pearl:Leucovorin (Folinic Acid) is Methotrexate's antidote. It is the reduced form of folate that can bypass the enzyme dihydrofolate reductase (which Methotrexate inhibits). Application: It Busting the myth of methotrexate chronic hepatotoxicity Nature Reviews Rheumatology Targeted brain delivery of methotrexate by glutathione PEGylated liposomes: How can the formulation make a difference? ScienceDirect